FMRI of hippocampal deep brain stimulation in the rodent brain
نویسندگان
چکیده
Background: Deep Brain Stimulation (DBS) is a promising treatment for neurological and psychiatric disorders. However, the underlying mechanism of action of DBS remains unknown. The effect of DBS has been studied primarily by direct neural recording studies, which lack the ability to elucidate DBS related responses on a whole-brain scale. Functional Magnetic Resonance Imaging (fMRI) reflects changes in neural activity throughout the entire brain volume and may thus reveal neuroanatomical connectivity of the targeted structure in vivo. In order to visualize the whole-brain blood oxygen level dependent (BOLD) responses to DBS, we have developed an MR-compatible electrode and an acquisition protocol for simultaneous DBS and BOLD fMRI. With this study, we aimed to demonstrate that DBS during fMRI is a valuable technique to investigate the whole-brain effect of DBS.
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